Can I use a combi boiler along with a pressurised hot water cylinder

Can I use a combi boiler along with a pressurised hot water cylinder to minimise pipe run in the house?
I want to put the combi boiler in the basement and use the hot water side to feed the kitchen,utility room and downstairs shower room whilst siting the water cylinder next to the bathroom on the first floor to serve that room and a shower in the loft. Is this a sensible use of a combi or should I use a system boiler and just take hot water from the unvented cylinder?
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